The introduction of a fluorine atom at the 4′-position led to a tri fluorinated gemcitabine analogue that exhibited potent activity but no selectivity against these three viruses.

Feb 4, 2021 · Western blot and quantitative reverse-transcription polymerase chain reaction analyses verified that gemcitabine blocked viral protein expression in virus-infected cells, not …

Feb 6, 2025 · This study identified gemcitabine, a nucleoside analog, as an effective anti-PEDV agent that targets the viral replication phase. The naturally occurring compound baicalein is …

Dec 31, 2019 · The most effective compounds against echovirus 30 were gemcitabine and rupintrivir, as demonstrated by their concentration-dependent activity. Gemcitabine affects the …

Apr 9, 2025 · Gemcitabine (GEM), a nucleoside analog chemotherapy agent, has been widely used in the treatment of various cancers. In recent years, there has been growing interest in …

Jul 17, 2024 · One of the primary mechanisms of Gemcitabine action is through the incorporation of dFdCTP into the DNA strand during the S-phase of the cell cycle. When dFdCTP is …

It disrupts DNA formation by mimicking a DNA building block. This slows or stops the growth of cancer cells and other rapidly growing cells.

When gemcitabine is given in combination with radiation treatment, you may develop inflammation of the lungs or soreness of the mouth and throat which can be life-threatening.

Patients may experience gemcitabine toxicity if the medication is infused for more than 60 minutes or if the medication is given more than once a week. Side effects of toxicity can include severe …

One of the most important explanations for the limited effect of gemcitabine is the rapid development of gemcitabine resistance in pancreatic cancer.