The Arizona Cardinals offense squandered opportunity after opportunity in a 16-15 loss to the San Francisco 49ers. They fell to 2-1 with the defeat.

Who won the Arizona Cardinals vs San Francisco 49ers game? Check out our updates, highlights and analysis from the NFL Week 3 game.

The walking-wounded Niners gutted out another victory, this time without their star defensive end, as a host of teammates ...

Recently signed kicker Eddy Pineiro made a 35-yard field goal on the final play to give the San Francisco 49ers a 16-15 win ...

The San Francisco 49ers struggled in their home opener, but they left Week 3 with a win vs. the Arizona Cardinals. Here are the highlights.

The first play in the final quarter brought some controversy, as the 49ers believed they got a safety on Murray, who threw the ball away for intentional grounding near the goal line - though replay ...

Here are five takeaways from the loss: The Cardinals defense gave the offense every chance. With 3:15 to play, Calais ...

The Cardinals had first-and-10 on their own 45-yard line when Kyler Murray dropped back and saw Harrison wide open downfield. He uncorked a perfect throw that hit Harrison right in the hands. Somehow, ...

Arizona Cardinals receiver Marvin Harrison Jr had social media buzzing for a play he didn't make against the San Francisco 49ers on Sunday, Sept. 21.

After two three-and-outs to open the game, Jones completed four straight passes on San Francisco’s third drive as the 49ers ...

San Francisco’s latest kicker drove a walk-off, 35-yard field goal through the uprights to give the 49ers a 16-15 victory over the Cardinals — pushing the team to 3-0 on the young season.

Arizona Cardinals tight end Trey McBride makes a 1-yard touchdown reception against the San Francisco 49ers during Week 3 of the 2025 NFL season.