What’s at stake, who’s better, key matchup to watch, TV info, fantasy sleeper and prediction for Sunday’s home game between the AFC West rivals.

Learn which TV channel or how to live stream the NFL Week 3 Los Angeles Chargers and Denver Broncos game, Sunday, Sept. 21.

Los Angeles is a 2.5-point favorite in the latest Broncos vs. Chargers odds from SportsLine consensus, while the over/under for total points scored is 46. The Chargers are -154 money line favorites (risk $154 to win $100),

The Denver Broncos (1-1) and LA Chargers (2-0) meet in a divisional face-off Sunday. Kickoff from SoFi Stadium in Inglewood, California, is set for 4:05 p.m. ET (CBS). Let's analyze BetMGM Sportsbook's NFL odds around the Broncos vs. Chargers odds and make our expert NFL picks and predictions for the best bets.

Here are five predictions for Sunday’s pivotal game at SoFi Stadium: The Chargers’ rookie out of North Carolina is a powerful and fast player who could not get untracked last week against the Raiders. Najee Harris didn’t fare much better as Justin Herbert led the Chargers in rushing.

The Broncos, however, are no pushover -- they took care of business in Week 1 against the Tennessee Titans, and they could've easily been 2-0 themselves had they been able to close out the Indianapolis Colts in Week 2. Having not done so, the Chargers can expect to get the best shot of an upstart Broncos team led by coach Sean Payton.

Preview the Denver Broncos' NFL Week 3 matchup with the Chargers, including live stream, TV channel, odds, and game information.

Preview the Week 3 matchup between the Los Angeles Chargers and Denver Broncos with predictions, odds, over/under, spread, betting lines and more.

Payton needs one victory to tie Bill Parcells for the 16th-most regular-season wins in NFL history. Payton springs off of the Parcells coaching tree, so this will be a sweet and symbolic achievement for the Broncos' head coach. Let's hope it happens at SoFi Stadium.

Through the first two games of the regular season, the Broncos have yet to play a clean or complete game. Doing so today would go along ways to a win.