T cell therapies have revolutionized cancer treatment—but so far, their success has been largely limited to blood cancers. Solid tumors, which account for around 90% of all adult cancers, remain a ...

To make the therapy safer and more adaptable, UChicago researchers developed a new “split” system called GA1CAR. This uses ...

Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the ...

As flu season approaches and public health officials roll out their annual push for vaccination, Allen Institute scientists ...

Once thought to be a flaw in the system, new research suggests that CD4 T cells may actually hold the key to maintaining a ...

By profiling over 16 million immune cells from people aged 22 to 65 after flu vaccination, scientists discovered that memory ...

Sickle cell disease (SCD) altered CD8+ T-cell chromatin architecture, triggering ferroptosis and weakening antitumor immunity. Hydrogen sulfide (H2S) treatment restored chromatin interactions and ...

CD19 chimeric antigen receptor T-cell therapy improved lung function and skin thickness in patients with severe refractory ...