San Francisco 49ers star defensive end Nick Bosa left the game against the Arizona Cardinals with a knee injury in the first half. Bosa left the field favoring his right leg after a third-down pass rush in the first quarter.

When you think of the 49ers, you think of them being a top-heavy team. The roster lacks quality or trusted depth, and they lean on their stars to win games. However, through three games, a lot of their big names have been up and down.

Quarterback Mac Jones, already serving in relief duty for the injured Brock Purdy, told reporters after Sunday's 16-15 win over the Arizona Cardinals that he reaggravated the same PCL sprain that hampered him during training camp.

The San Francisco 49ers entered Week 3 against the Arizona Cardinals without several important offensive players. Quarterback Brock Purdy and receiver Jauan Jennings were initially questionable to play on the final injury report of the week, but they were both downgraded Sunday morning.

Eddy Pineiro has kicked a 35-yard field goal to give the San Francisco 49ers a 16-15 win over the Arizona Cardinals.

San Francisco 49ers defensive coordinator Robert Saleh, offensive coordinator Klay Kubiak, and quarterbacks Brock Purdy and Mac Jones addressed reporters following Thursday's practice as the team prepares for its Week 3 matchup against the Arizona Cardinals. Here's everything...

The 49ers needed a big drive from Mac Jones to remain undefeated. And they got just that from the former Patriots quarterback.

SANTA CLARA, Calif. — Arizona Cardinals running back James Conner was taken off the field on a cart with a right ankle injury in the third quarter of their loss to the San Francisco 49ers on Sunday. Conner's leg buckled underneath him as he was tackled on a short run and members of the Cardinals' training staff immediately ran onto the field.