Sept. 21, 2:20 p.m. PT Star 49ers edge rusher Nick Bosa went down with a knee injury late in the first quarter of Sunday's ...

Star tight end George Kittle suffered a hamstring injury in the first week of the season that landed him on injured reserve.

The 49ers (3-0) are cooking up wild wins despite injuries continue to rob them, with Nick Bosa being the latest and ...

NFL.com keeps you up to date with all of the latest league news from around the NFL. Visit NFL.com's transaction hub for a ...

San Francisco rookie defensive end Mykel Williams also went back to the locker room in the first half with a wrist injury, ...

The 49ers are concerned about Nick Bosa’s knee injury, but they overcame an ugly game to earn a third straight win.

McCaffrey averaged just 3.1 yards per carry and took everything the Arizona defensive line have to offer. Linebacker Mack ...

Who won the Arizona Cardinals vs San Francisco 49ers game? Check out our updates, highlights and analysis from the NFL Week 3 game.

Bosa entered Sunday's divisional clash with two sacks through two games – one in each of his first two games. An injury to the edge rusher would mark a fourth injured star player for the 49ers already ...

The walking-wounded Niners gutted out another victory, this time without their star defensive end, as a host of teammates ...

The 49ers (3-0) won their home opener 16-15 on Eddy Pineiro’s walk-off field goal against the Arizona Cardinals.

The 49ers (3-0) won their home opener 16-15 on Eddy Pineiro’s walk-off field goal against the Arizona Cardinals.