James Conner suffered a gruesome lower-body injury in the second half of the Cardinals ' game against the 49ers, a tough blow for the Arizona rushing attack. Conner was carted off the field, with the majority of players from both teams gathering around him to show support.

Both Los Angeles Chargers running back Najee Harris and Arizona Cardinals halfback James Conner appeared to suffer major injuries on Sunday, calling into question their availability for the foreseeable future.

Arizona Cardinals running back James Conner's 6-yard rush is negated by offsetting penalties against both teams during Week 3 of the 2025 NFL season.

Running back Tony Pollard and the Tennessee Titans take on divisional rivals, the Indianapolis Colts, in Week 3 on Sunday afternoon.