The prevalence of homologous recombination DNA damage repair (HR-DDR) deficiencies among all tumor lineages is not well characterized. Therapy directed toward homologous recombination DDR deficiency ...

Responsiveness to Immune Checkpoint Inhibitors Is Associated With a Peripheral Blood T-Cell Signature in Metastatic Castration-Resistant Prostate Cancer Patients with LMS treated at Memorial Sloan ...

The Association for Molecular Pathology announced the publication of best practice recommendations for clinical laboratories developing and performing homologous recombination deficiency (HRD) testing ...

To test the contribution of homologous recombinational repair (HRR) in repairing DNA damage sites induced by high-energy iron ions, we used (1) HRR-deficient rodent cells carrying a deletion in the ...

Two articles detail how human RecQ helicases regulate homologous recombination and protect genome stability. Taken together, these papers lend new insight into the molecular function of human RecQ ...

A recent study, undertaken by researchers at the Tokyo Metropolitan University and the Tokyo Metropolitan Institute of Medical Science (both Japan), unravels key steps in the process of homologous ...

Homologous recombination (HR) is an important process that plays multiple crucial roles during meiosis, a type of cell cycle dedicated to sexual reproduction. During HR, homologous DNA molecules ...

Since sister chromatids are identical to each other, recombination with a sister chromatid is expected, in most cases, to be a precise way for repairing DNA damage. Recombination between 2 different ...

Sensitivity to ionizing radiation is compelling evidence that BRCA1-and BRCA2-deficient cells are defective in repair of DSBs. As discussed above, 2 separate pathways play major roles in DSB repair in ...

Professor Neil Hunter, Department of Microbiology and Molecular Genetics, has been elected as a Fellow of the Royal Society of the United Kingdom. Hunter, how is also an HHMI Investigator, studies the ...

Precision gene editing is crucial for treating genetic diseases, as it enables targeted correction of specific mutations. A Korean research team has become the first in the world to significantly ...