Regulatory mechanisms governing stem cell quiescence in glandular organs remain ill-defined. Here, multi-omics profiling ...
As we look ahead in 2025, the pace of discovery in genetics continues to accelerate, marking the third decade of the 21st century with remarkable ...
Titled “A comparison of integration methods for single‐cell RNA sequencing data and ATAC sequencing data”, this paper ...
Lifelong viral infections can quietly alter the immune system, with effects that persist over the time. Viruses such as the ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Thousands of genes and regulatory elements are ...
Abstract: Genome regulatory elements are fundamental to cellular identity and cell type specific gene expression. Understanding how the underlying genetic code is differentially utilised by different ...
Contributed by Howard Y. Chang; received November 19, 2024; accepted February 20, 2025; reviewed by Jellert Gaublomme and David A. Quigley The spatial organization of cells within tissues plays a ...
New addition to PacBio Compatible program enables scientists to connect genetic variation with gene regulation in a single assay, advancing research in rare disease and cancer MENLO PARK, Calif., Sept ...
Direct reprogramming of fibroblasts to cardiomyocytes is a potentially curative strategy for ischemic heart disease. However, current reprogramming strategies require excessive factors due to ...
This study introduces ambisim, a rigorously validated and well-documented simulation framework that enables the generation of synthetic, genotype-aware single-cell RNA and ATAC sequencing datasets ...
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