A UPS cargo plane crashed in Louisville on Tuesday, Nov. 4, killing at least 12 people. Find out more about state of emergency and cause of crash.

Nine people were killed and 11 injured after a UPS MD-11 freighter crashed and exploded shortly after takeoff from Louisville. The NTSB and FAA are investigating, with early focus on a possible engine separation.

Video shows a massive fireball and smoke after UPS Flight 2976 crashed into a Kentucky Petroleum Recycling building during takeoff at the Louisville airport.

Video showed flames on the plane’s left wing and a trail of smoke. The plane then lifted slightly off the ground before crashing and exploding in a huge fireball.

Investigators said several explosions occurred after the plane crashed as it hit businesses that contained hazardous material. The last time a UPS plane crashed was in August 2013. An Airbus A300 crashed on an early-morning approach into Birmingham, Ala., killing the two pilots.

The plane crashed as it was departing for Honolulu from UPS Worldport at Louisville Muhammad Ali International Airport in Louisville.

Federal teams are on the scene after a UPS MD-11 cargo jet went down shortly after takeoff Tuesday from Louisville, Kentucky.

Investigators say nine people are still missing after Tuesday's UPS plane crash that left at least 13 people dead. Among those killed were three UPS pilots operating the flight. Witnesses are trying to process what they experienced,