Penn State’s opponent this week is the number two-ranked Indiana Hoosiers. What’s been going well for Indiana this season that has them undefeated so far? Well, analyst for FOX59/CBS4 Sports Chris Widlic says that its everything.

Preview the Nov. 8 matchup between the Indiana Hoosiers and Penn State Nittany Lions with predictions, odds, over/under, spread, betting lines and more.

Indiana: Cal transfer Fernando Mendoza (15) has blossomed into a star with the Hoosiers. He’s passed for 25 touchdowns against only four interceptions. Mendoza is also a threat on the ground with four scores. He is averaging 4.4 yards per carry.

Penn State, of course, is unranked in the inaugural CFP rankings after losing its fifth straight game. Still, Indiana coach Curt Cignetti found a ranking to pitch his team in girding against the upset as 13.5-point favorites. Hello, ESPN FPI!

Our college football Week 11 picks for UofL vs Cal, UK vs Florida, Wake Forest vs Virginia, FSU vs Clemson and Indiana vs Penn State.

If this Penn State team played No. 2 Indiana 10 times on a neutral field, the Hoosiers would probably win all 10 games. But Curt Cignetti’s 9-0 Hoosiers have to come to Beaver Stadium for Saturday afternoon’s Big Ten matchup.

Penn State has fallen to 0-5 in the Big Ten, but Indiana coach Curt Cignetti sees talented players who will pose a challenge Saturday in Happy Valley.

Find single game tickets to the Indiana Hoosiers vs. Penn State Nittany Lions college football Week 11 matchup on Saturday, November 8, 2025 at West

The Athletic still projects Penn State to make a bowl game, with an intriguing matchup against rival Pitt in the Pinstripe Bowl on Dec. 27 at Yankee Stadium. USA Today has the Lions squaring off with Miami (OH) in the GameAbove Sports Bowl on Dec. 26 at Ford Field in Detroit.