SCD-HeFT also compared primary therapy with amiodarone with placebo; amiodarone had no effect on survival. The 2521-patient trial was conducted at 148 centers in North America and New Zealand.

Drs Eric Topol and Rob Califf discuss SCD-HeFT, PROVE-IT and SYNERGY.

The pain and impact of sickle cell disease (SCD) was associated with patient social and emotional functioning in a recent study.