Identification of variants influences treatment decisions. Inhibitors of the poly-ADP-ribose polymerase (PARP) system, a pathway for repairing single-stranded DNA breaks, are recommended for tumors ...

Using optical tweezers, researchers at National Taiwan University have observed individual binding events in real time, ...

Maria Jasin, PhD, whose research on DNA repair has transformed our understanding of cancers, has been selected as the 2025 recipient of the Greengard Prize.

Lymphocyte Infiltration Score and Spatial Characteristics Refined the Prognosis and Denosumab Treatment Responsiveness Indicators for Giant Cell Tumor of Bone Outcomes data for DNA-damaging ...

This is a preview. Log in through your library . Abstract Homologous recombination is a key process for maintaining genome integrity and diversity. In eukaryotes, the nucleosome structure of chromatin ...

Using optical tweezers, researchers observed individual binding events in real time, offering new insights into the molecular ...

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Dr Liu is a ...

The protooncoprotein N-Myc, which is overexpressed in approximately 25% of neuroblastomas as the consequence of MYCN gene amplification, has long been postulated to regulate DNA double-strand break ...

Plant genome editing through CRISPR-Cas holds transformative potential, yet its precision remains hampered by low gene targeting (GT) efficiency. This study presents a strategy to enhance CRISPR-based ...