New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and ...
New study shows that targeting an oft-drugged family of cell membrane receptors with biased modulators can expand potential ...
About one-third of all drugs approved by the Food and Drug Administration target the largest family of cell membrane ...
Septerna's Native Complex platform isolates GPCRs in their native form, enabling advanced drug discovery for previously undruggable targets, including oral small-molecule therapeutics. Lead molecule ...
G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...
G protein-coupled receptors (GPCRs) for hormones and neurotransmitters evolved to be the most important means of communication between cells and tissues in higher organisms. They are responsive to a ...
About one-third of all drugs approved by the Food and Drug Administration target the largest family of cell membrane receptors called G ...
Researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel drug ...
Proteins are life’s engines, powering processes like muscle movement, vision, and chemical reactions. Their environments—water, lipid membranes, or other condensed phases—are critical to their ...
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