The serine proteinase plasmin is the key fibrinolytic enzyme that dissolves blood clots and also promotes cell migration and tissue remodeling. Here, we report the 2.65 Å crystal structure of a ...

How an enzyme activates its substrate for turnover is fundamental for catalysis but incompletely understood on a structural level. With redox enzymes one typically analyses structures of ...

A research team has solved the crystal structure for an enzyme that plays a key role in DNA methylation, the process by which methyl groups are added to the DNA molecule. The breakthrough reveals how ...

Researchers at the University of Basel have repurposed a natural enzyme so that it catalyzes a highly challenging chemical reaction. Their approach opens new possibilities for synthesizing complex ...

Enzymes are essential for life and are one of the most important types of protein in the human body. Studying enzyme kinetics provides information about the diverse range of reactions in the human ...

Researchers at the University of Basel have repurposed a natural enzyme so that it catalyzes a highly challenging chemical reaction. Their approach opens new possibilities for synthesizing complex ...

Researchers have been making impressive progress lately in efforts to untangle the mysteries of knotted proteins. Three independent surveys have identified the same enzyme as having the most complex ...

Particulate membrane preparations isolated from cambial cells and differentiating and differentiated xylem cells of pine (Pinus sylvestris L.) trees synthesised [14C]glucans using either guanosine ...

https://doi.org/10.1899/09-024.1 https://www.jstor.org/stable/10.1899/09-024.1 AbstractWe examined how substrate and complex hydraulic variables limit the ...

The γ-secretase enzyme can cleave more than 150 membrane proteins. These include the amyloid precursor protein, which produces deposits linked to Alzheimer’s disease, and the Notch1 protein, which is ...