Researchers reveal how DNA gyrase resolves DNA entanglements. The findings not only provide novel insights into this fundamental biological mechanism but also have potential practical applications.

Picture in your mind a traditional "landline" telephone with a coiled cord connecting the handset to the phone. The coiled telephone cord and the DNA double helix that stores the genetic material in ...

Researchers from Durham University, Jagiellonian University (Poland) and the John Innes Centre have achieved a breakthrough in understanding DNA gyrase, a vital bacterial enzyme and key antibiotic ...

Using high-resolution cryo-electron microscopy (cryo-em), researchers from Durham University, Jagiellonian University, and the John Innes Centre uncovered unprecedented detail of gyrase’s action on ...

Researchers from Durham University, Jagiellonian University (Poland) and the John Innes Centre have achieved a breakthrough in understanding DNA gyrase, a vital bacterial enzyme and key antibiotic ...

DNA gyrase, a bacterial type II topoisomerase, is instrumental in maintaining DNA supercoiling during replication and transcription. Owing to its absence in higher eukaryotes, it represents an ...

DNA gyrase, a type II topoisomerase, introduces negative supercoils into DNA using ATP hydrolysis. The highly effective gyrasetargeted drugs, fluoroquinolones (FQs), interrupt gyrase by stabilizing a ...

Scientists say they have identified a critical mechanism that allows deadly bacteria to gain resistance to antibiotics. The findings, “The pentapeptide-repeat protein, MfpA, interacts with ...

DNA gyrase has been purified to near homogeneity from Escherichia coli. The enzyme consists of two subunits of molecular weights 90,000 and 100,000 present in roughly equimolar amounts. The subunits ...