49ers DE injures knee in game vs. Cardinals
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49ers downgrade Brock Purdy, Jauan Jennings
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Niners Wire on MSN
49ers' starting cornerback suffers injury in third quarter vs. Cardinals
The San Francisco 49ers have dealt with plenty of offensive injuries this year, but the defense is taking several hits in Week 3.
Arizona Cardinals running back James Conner was taken off the field on a cart with a right ankle injury in the third quarter of Sunday’s game against the San Francisco 49ers. The Pitt product’s leg bu
Xavier Thomas, Bam Knight and Xavier Weaver are also inactive for the Cardinals today in San Francisco. As for the 49ers, they previously ruled out Jauan Jennings and Brock Purdy - leaving Mac Jones for his second start of the season. The Cardinals hope to reach a 3-0 record for the first time since 2021.
The San Francisco 49ers (2-0) host an NFC West showdown against the Arizona Cardinals (2-0) on Sunday, September 21, 2025 at Levi's Stadium. Date: Sept. 21
San Francisco 49ers vs Arizona Cardinals picks, predictions, odds, win probabilities for NFL Week 3 Sunday game on Sept. 21, 2025. Who will win today?
The Arizona Cardinals are set to take on the San Francisco 49ers on the road this weekend to open NFC West division play. Arizona managed to sweep San Francisco
SB Nation on MSN
49ers vs. Cardinals game thread: Advantage, Niners pass rush
If the Cardinals are forced to be one-dimensional, the Niners’ defensive line has the advantage. Arizona is down Paris Johnson, and a Nick Bosa versus Kelvin Beachum matchup could be all it takes to swing this game. The winner of this game will be leading the NFC West.
What channel is Arizona Cardinals vs San Francisco 49ers game on today? How to watch NFL Week 3 football game on TV, streaming Sunday, Sept. 21, 2025.
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