The San Francisco 49ers gritted out a win at home against the Arizona Cardinals. Mac Jones completed 20 of 21 passes of 0-9 air yards for 154 yards and a touchdown. He was precise, under control, and apparently playing through the same PCL injury he suffered in training camp. That injury prevented Jones from playing in the preseason finale.

With all the injuries they've had to deal with, the San Francisco 49ers have plenty of excuses not to win games.

At long last, someone has scored a touchdown in Cardinals-49ers. Mac Jones tossed a 1-yard score to fullback Kyle Juszczyk to give San Francisco a 13-6 lead in the fourth quarter of Sunday's divisional matchup.

We break down the fantasy football outlook of Mac Jones ahead of the 49ers’ Week 3 matchup against the Cardinals.

San Francisco is a 2.5-point favorite in the latest Cardinals vs. 49ers odds from SportsLine consensus, while the over/under for total points scored is 44.5. The 49ers are -128 money line favorites (risk $128 to win $100),

San Francisco 49ers defensive coordinator Robert Saleh, offensive coordinator Klay Kubiak, and quarterbacks Brock Purdy and Mac Jones addressed reporters following Thursday's practice as the team prepares for its Week 3 matchup against the Arizona Cardinals. Here's everything...

Christian McCaffrey Mac Jones National Football League NFL - Arizona Cardinals vs. San Francisco 49ers - 09/21/2025 San Francisco 49ers

San Francisco 49ers QB Mac Jones threads a 34-yard pass to WR Ricky Pearsall along the sideline against the Arizona Cardinals in Week 3 of the 2025 season.

San Francisco 49ers quarterback Mac Jones throws a 1-yard touchdown pass to fullback Kyle Juszczyk against the Arizona Cardinals during Week 3 of the 2025 NFL season.

Kyle Shanahan could have San Francisco 49ers future on trading up for a quarterback in 2021. The Niners gave three first-round picks and a third-rounder to the Miami Dolphins to go from 12th to