Josh Weinfuss of ESPN revealed that sources have indicated that the right ankle injury Connor suffered is season-ending. This has yet to be confirmed, but the way that the Cardinals’ back was carted off the field pointed to things being very serious.

‘WAY too many injuries today…,” NFL reporter Arye Pulli said. “Cardinals RB James Conner is being carted off the field after being tackled very awkwardly. The broadcast did not show the replay– very telling of the severity of the injury.”

Arizona Cardinals running back James Conner's 6-yard rush is negated by offsetting penalties against both teams during Week 3 of the 2025 NFL season.

Preview the player prop betting lines, stats and more for James Conner before his Arizona Cardinals play the San Francisco 49ers in a Week 3 NFL

It was a rough day for injuries in the late window in Week 3 with two key fantasy football running backs going down. First, it was Los Angeles Chargers RB Najee Harris, who appeared to suffer a non-contact lower-leg injury.

Najee Harris appeared to sustain an Achilles injury during the Los Angeles Chargers' Week 3 matchup against the Denver Broncos on Sunday