Arizona Cardinals running back James Conner suffered what appeared to be a very serious ankle injury during Sunday's matchup against the San Francisco 49ers and had to be carted off the field.

Arizona Cardinals running back James Conner's 6-yard rush is negated by offsetting penalties against both teams during Week 3 of the 2025 NFL season.

Running back Tony Pollard and the Tennessee Titans take on divisional rivals, the Indianapolis Colts, in Week 3 on Sunday afternoon.

Both Los Angeles Chargers running back Najee Harris and Arizona Cardinals halfback James Conner appeared to suffer major injuries on Sunday, calling into question their availability for the foreseeable future.