When Jacksonville visits Houston on Sunday, the Jaguars will get a boost with new receiver Jakobi Meyers while the Texans will be missing their top offensive star with quarterback C.J. Stroud recovering from a concussion.

AFC South rivalry between Houston Texans and Jacksonville Jaguars grows more intense with recent history and playoff implications.

That said, a sixth win for Jacksonville will give the Jags a season sweep over the Texans for the first time since 2017 and move Jacksonville into prime position to catch the Colts. But, a fourth win for the Texans in the 2025 season will give them life as the campaign heads into the second half of the season.

Heading into the Texans' Week 10 matchup vs. the Jacksonville Jaguars for the third game of their extended home stretch, Houston is slotted in as the early betting favorites to win (-1.5, -125 moneyline) per DraftKings odds, even when factoring in C.J. Stroud's status being up in the air with a concussion.

Jacksonville Jaguars quarterback Trevor Lawrence’s voice didn’t shutter or shake when he said it. He stood in the post-game press conference room inside the bowels of EverBank Stadium after his team pulled off a 17-10 victory against the Houston Texans on Sept. 21 and was asked about the chippiness between the two teams.