This article was originally published on www.si.com/nfl/cardinals as Cardinals’ Kyler Murray Joins Josh Allen in NFL History. In their Week 3 battle against the San Francisco 49ers, the Arizona Cardinals have seen quarterback Kyler Murray make NFL history.

Arizona Cardinals quarterback Kyler Murray is entering a pivotal 2025 NFL campaign in which he may have to prove that he is actually a franchise player in the desert moving forward, but things could be getting off to a rocky start.

San Francisco is a 2.5-point favorite in the latest Cardinals vs. 49ers odds from SportsLine consensus, while the over/under for total points scored is 44.5. The 49ers are -150 money line favorites (risk $150 to win $100),

Arizona Cardinals head coach Jonathan Gannon highlighted quarterback Kyler Murray as a key reason for his team's 2-0 start. It's easy to see why.

Aug 9, 2025; Glendale, Arizona, USA; Arizona Cardinals quarterback Kyler Murray (1) reacts after a yellow penalty flag is thrown against the Kansas City Chiefs during a preseason NFL game at State Farm Stadium. Mandatory Credit: Mark J. Rebilas-Imagn Images / Mark J. Rebilas-Imagn Images

The Arizona Cardinals are off to a hot start (2-0) on the field. But off the field? Their quarterback Kyler Murray has gotten into some hot water because of a very questionable photoshoot that featured the 28-year-old athlete posing with a pit bull and wearing a Michael Vick jersey.

Cardinals quarterback Kyler Murray is apologizing for a social media post in which he wore a Michael Vick jersey while posing with a dog. The photo led to outcry on Wednesday, Sept. 17 about animal cruelty as Vick was famously spent time in prison for orchestrating a dog fighting ring.

Arizona Cardinals quarterback Kyler Murray removed a post and apologized after he wore a Michael Vick jersey while posing with his dog.