The San Francisco 49ers are unbeaten and alone in first place, but a pall hangs over the team after Nick Bosa became their latest star to be forced off the field by an injury.

San Francisco 49ers kicker Eddy Piñeiro, center, celebrates his game-winning field goal after an NFL football game against the Arizona Cardinals, Sunday, Sept. 21, 2025, in Santa Clara, Calif.

The San Francisco 49ers had to finish the end of their contest against the Arizona Cardinals without a key piece of the defense.

When you think of the 49ers, you think of them being a top-heavy team. The roster lacks quality or trusted depth, and they lean on their stars to win games. However, through three games, a lot of their big names have been up and down.

The San Francisco 49ers have dealt with plenty of offensive injuries this year, but the defense is taking several hits in Week 3.

With all the injuries they've had to deal with, the San Francisco 49ers have plenty of excuses not to win games.

The 49ers (3-0) won their home opener 16-15 on Eddy Pineiro’s walk-off field goal against the Arizona Cardinals.

James Conner was forced to exit the Cardinals' divisional clash against the 49ers due to what the team is calling an ankle injury.

Learn which TV channel or how to live stream the NFL Week 3 San Francisco 49ers and Arizona Cardinals game, Sunday, Sept. 21.

The San Francisco 49ers continue to get hit by the injury bug, as the team has revealed the status for both quarterback Brock Purdy and wide receiver Jauan Jennings.